49,309 research outputs found
Initial claims and employment growth: are we at the threshold?
One common threshold is that labor market conditions are improving when weekly unemployment claims fall below 400,000.Unemployment ; Employment ; Labor market
Using Ontology Fingerprints to evaluate genome-wide association study results
We describe an approach to characterize genes or phenotypes via ontology fingerprints which are composed of Gene Ontology (GO) terms overrepresented among those PubMed abstracts linked to the genes or phenotypes. We then quantify the biological relevance between genes and phenotypes by comparing their ontology fingerprints to calculate a similarity score. We validated this approach by correctly identifying genes belong to their biological pathways with high accuracy, and applied this approach to evaluate GWA study by ranking genes associated with the lipid concentrations in plasma as well as to prioritize genes within linkage disequilibrium (LD) block. We found that the genes with highest scores were: ABCA1, LPL, and CETP for HDL; LDLR, APOE and APOB for LDL; and LPL, APOA1 and APOB for triglyceride. In addition, we identified some top ranked genes linking to lipid metabolism from the literature even in cases where such knowledge was not reflected in current annotation of these genes. These results demonstrate that ontology fingerprints can be used effectively to prioritize genes from GWA studies for experimental validation
Symbolic Dynamics Analysis of the Lorenz Equations
Recent progress of symbolic dynamics of one- and especially two-dimensional
maps has enabled us to construct symbolic dynamics for systems of ordinary
differential equations (ODEs). Numerical study under the guidance of symbolic
dynamics is capable to yield global results on chaotic and periodic regimes in
systems of dissipative ODEs which cannot be obtained neither by purely
analytical means nor by numerical work alone. By constructing symbolic dynamics
of 1D and 2D maps from the Poincare sections all unstable periodic orbits up to
a given length at a fixed parameter set may be located and all stable periodic
orbits up to a given length may be found in a wide parameter range. This
knowledge, in turn, tells much about the nature of the chaotic limits. Applied
to the Lorenz equations, this approach has led to a nomenclature, i.e.,
absolute periods and symbolic names, of stable and unstable periodic orbits for
an autonomous system. Symmetry breakings and restorations as well as
coexistence of different regimes are also analyzed by using symbolic dynamics.Comment: 35 pages, LaTeX, 13 Postscript figures, uses psfig.tex. The revision
concerns a bug at the end of hlzfig12.ps which prevented the printing of the
whole .ps file from page 2
Raman spectroscopic determination of the length, strength, compressibility, Debye temperature, elasticity, and force constant of the C-C bond in graphene
From the perspective of bond relaxation and vibration, we have reconciled the
Raman shifts of graphene under the stimuli of the number-of-layer,
uni-axial-strain, pressure, and temperature in terms of the response of the
length and strength of the representative bond of the entire specimen to the
applied stimuli. Theoretical unification of the measurements clarifies that:
(i) the opposite trends of Raman shifts due to number-of-layer reduction
indicate that the G-peak shift is dominated by the vibration of a pair of atoms
while the D- and the 2D-peak shifts involves z-neighbor of a specific atom;
(ii) the tensile strain-induced phonon softening and phonon-band splitting
arise from the asymmetric response of the C3v bond geometry to the C2v
uni-axial bond elongation; (iii) the thermal-softening of the phonons
originates from bond expansion and weakening; and (iv) the pressure- stiffening
of the phonons results from bond compression and work hardening. Reproduction
of the measurements has led to quantitative information about the referential
frequencies from which the Raman frequencies shift, the length, energy, force
constant, Debye temperature, compressibility, elastic modulus of the C-C bond
in graphene, which is of instrumental importance to the understanding of the
unusual behavior of graphene
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